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Sedona Murphy

DNA is packaged into the nucleus of a cell and is organized by various proteins to turn on or off specific genes. Polycomb Group Proteins (PcGs) interact with DNA to three-dimensionally fold the DNA in a way that represses target regions, preventing genes from turning on at the wrong time or place. This process is dynamic and is used during development to ensure proper spatial and temporal expression of genes. PcGs are used in organisms such a fruit flies, mice, and humans to properly repress genes. Dysregulation of this system leads to developmental disorders and even some cancers. I am studying how PcGs regulate the 3D folding of DNA, and what role this 3D structure has in making sure that genes stay off. By combining polymer modelling, super-resolution microscopy, and new genetic tools, I will test how PcG-mediated organization of DNA maintains a repressive state despite a changing cellular environment.