In recent years, the development of new implantable-device technologies to read-out and write-in electrical and chemical signals to and from the brain have created unprecedented opportunities to understand normal brain function and to ameliorate dysfunction resulting from disease or injury. I’m working on creating a next-generation brain-machine interface, extending the powers of modern electronics to reach deep areas of the brain. To do this, I fabricate arrays of ultra-sharp microwire electrodes mated to CMOS chips, which already have millions of pixels. By integrating these two technologies, we can read and write the electrical information of neurons from each individual wire simultaneously. This allows us to interface with the brain at an unprecedented level, revolutionizing the way we can treat neurodegenerative diseases, as well as reveal fundamental new insights into how sensory information is represented in the activity of neural networks.